Yes it is fully Vegan Society approved
- Normal blood clotting: It helps activate proteins required for healthy coagulation and wound healing.
- Bone health: It activates osteocalcin, a protein involved in incorporating calcium into bone, thereby supporting bone strength and maintenance.
- Cardiovascular health: Vitamin K activates matrix Gla-protein, which may help regulate calcium deposition in arterial walls. However, supplements should not be presented as preventing or treating cardiovascular disease.
People taking blood-thinning medications, individuals with severe liver disease, and those on kidney dialysis should avoid vitamin K supplements unless directed by a doctor.
Combining vitamin K1, MK-4 and MK-7 provides complementary biological activity and tissue distribution compared to single-form vitamin K supplements:
- Bus, K. and Szterk, A. Relationship between Structure and Biological Activity of Various Vitamin K Forms. Nutrients. 2021 Dec 17;13(12):3136
- Shearer, M.J. and Newman, P. Metabolism and cell biology of vitamin K. Thromb Haemost. 2008 Oct;100(4):530-47
- Villa, J.K.D. et al. Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences. Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970
Only the all-trans forms of vitamin K are biologically active, making isomer quality an important consideration in vitamin K supplements:
- Cirilli, I. et al. Carboxylative efficacy of trans and cis MK-7 and comparison with other vitamin K isomers. BioFactors. 2022 Sep;48(5):1129-1136
- Lal, N. and Berenjian, A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Appl Microbiol Biotechnol. 2020 Apr;104(7):2765-2776
- Szterk, A. et al. Identification of cis/trans isomers of menaquinone-7 in food as exemplified by dietary supplements. Food Chem. 2018 Mar 15;243:403-409
Each form is provided at levels consistent with clinically studied intakes:
- Binkley, N. et al. A high phylloquinone intake is required to achieve maximal osteocalcin γ-carboxylation. Am J Clin Nutr. 2002 Nov;76(5):1055-60
- Knapen, M.H.J. et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-2507
- Nakamura, E. et al. Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. Nutr J. 2014 Aug 27;13:85

