Pure L-Methylfolate 400mcg, Vegan & Clean Label, Methylated Form of Folic Acid 5-MTHF (Vitamin B9)
Great for: pregnancy support, heart health, mood and brain function
Pure L-Methylfolate 400µg is a clean-label, hypoallergenic folate supplement formulated by Igennus nutrition scientists to work in harmony with the body. Pure L-Methylfolate delivers an optimal daily dose of 400µg folate in the body-ready and fully methylated form, ideal for providing health benefits without upsetting homeostasis. Each bottle delivers 180 small, easy-to-swallow tablets offering a 6 month supply.
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5-methyltetrahydrofolate (5-MTHF) is the metabolically active form of folate, the preferred form for MTHFR gene variants, raising levels 1.8x higher than folic acid
Women planning pregnancy, pregnant people, and those in the early postnatal period who need to ensure adequate folate intake to reduce the risk of neural tube defects and support fetal development. Adults who want to support normal homocysteine metabolism, cardiovascular and neurological health, mood and cognitive function, or who have low dietary folate intake. It’s also suitable for vegetarians/vegans who may have limited folate sources
MTHFR gene variants can reduce the enzyme activity that converts synthetic folic acid into 5‑MTHF. Taking L‑methylfolate supplies the active form directly, bypassing the impaired conversion and ensuring tissues receive usable folate.
L‑methylfolate is the natural, active form of folate the body uses in one‑carbon metabolism (DNA synthesis/repair, methylation) and neurotransmitter synthesis. It eliminates dependence on the multi‑step enzymatic conversion of folic acid, which varies between individuals (genetics, age, medications, gut health). High intake of synthetic folic acid can lead to detectable unmetabolized folic acid in the blood; using 5‑MTHF prevents accumulation of unmetabolized folic acid.
